First Author | Müller-Seitz M | Year | 1993 |
Journal | Genomics | Volume | 18 |
Issue | 3 | Pages | 559-61 |
PubMed ID | 8307566 | Mgi Jnum | J:16159 |
Mgi Id | MGI:64249 | Doi | 10.1016/s0888-7543(05)80356-8 |
Citation | Muller-Seitz M, et al. (1993) Chromosomal localization of the mouse titin gene and its relation to muscular dystrophy with myositis and nebulin genes on chromosome 2. Genomics 18(3):559-61 |
abstractText | In the mouse, the genes for the structural components of the myofibril titin and nebulin, Ttn and Neb, map to proximal Chr 2, as does the gene for a muscle disease, muscular dystrophy with myositis, mdm. To facilitate the evaluation of Ttn and Neb as possible candidates for mdm, we have determined their relative map positions, using a Mus spretus/Mus musculus interspecific backcross. The gene order (distances in cM) cenVim-16.9 +/- 4.7-Neb-7.6 +/- 3.0-Ttn, Acra-18.0 +/- 4.9-Pax-6-17.7 +/- 4.9-a ... has been determined. Considering the standard deviations, Neb, Ttn, and Acra could colocalize with mdm. Using Ttn and Neb probes, DNAs from mdm/mdm and mdm/+ mice were tested for restriction fragment variants in comparison to the M. musculus wildtype. No variants have been found with 11 restriction nucleases. Our data corroborate a conserved synteny comprising genes NEB, TTN, CHRNA1 on human Chr 2q. |