| First Author | Ahmad AM | Year | 2005 |
| Journal | Dev Dyn | Volume | 233 |
| Issue | 1 | Pages | 88-94 |
| PubMed ID | 15765507 | Mgi Jnum | J:97465 |
| Mgi Id | MGI:3575482 | Doi | 10.1002/dvdy.20320 |
| Citation | Ahmad AM, et al. (2005) Delayed and disturbed morphogenesis of the umbilical blood vessels in insulin-like growth factor-II deficient conceptuses (Igf2m+/p-). Dev Dyn 233(1):88-94 |
| abstractText | Insulin-like growth factor-II (IGF-II) deficiency occurs when a conceptus inherits an inactive gene from the father (Igf2m+/p-): fetal wet weight is reduced to 60% of wild-type, with the decline starting at E11. The umbilical cord vessels of mutant and wild-type were compared. At E8.0-E8.5, the timing of somite formation and chorioallantoic fusion was not altered. At E14.5-E16.5, the left umbilical artery degenerated approximately 1 day later in Igf2m+/p- conceptuses when compared with the wild-type. In the common umbilical artery at E15.5, muscle volume was reduced by one third in IGF-II deficiency. Treating the umbilical arteries as ideal tubes, the values of radius(4)/length suggest that blood flow through the placenta may be reduced by more than half in the Igf2m+/p- conceptuses. Developmental Dynamics 233:88-94, 2005. (c) 2005 Wiley-Liss, Inc. |
