| First Author | Hetts SW | Year | 1997 |
| Journal | J Neurosci Res | Volume | 50 |
| Issue | 6 | Pages | 958-66 |
| PubMed ID | 9452010 | Mgi Jnum | J:45052 |
| Mgi Id | MGI:1101666 | Doi | 10.1002/(SICI)1097-4547(19971215)50:6<958::AID-JNR6>3.0.CO;2-C |
| Citation | Hetts SW, et al. (1997) Expression and imprinting of the insulin-like growth factor II gene in neonatal mouse cerebellum. J Neurosci Res 50(6):958-66 |
| abstractText | Insulin-like growth factor II (IGF-II) plays significant roles in the growth and development of mammals through the regulation of mitogenesis and cell survival. Previously, IGF-II mRNA transcripts within the CNS were detected in the choroid plexus and leptomeninges (DeChiara et al., 1991). The objective of this study was to determine the expression pattern of IGF-II mRNA in different cell types of the cerebellum during development. We report here that the IGF-II gene is transcribed in granule and glial cells within the cerebellar parenchyma at various times during the early postnatal period in mice. IGF-II gene expression is further regulated by parent-specific imprinting such that only the paternal IGF-II allele is expressed in granule cells. In contrast, choroid plexus and leptomeninges express IGF-II mRNAs biallelically, indicating that cell type-specific regulation of genomic imprinting occurs within the mammalian CNS. |
