Primary Identifier | MGI:2663633 | Allele Type | Targeted |
Gene | Pdgfra | Transmission | Germline |
Strain of Origin | 129S4/SvJaeSor | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The gene was disrupted by a knock-in vector consisting of a Pdgfra/Fgfr1 fusion protein and a PGK-neo cassette. The fusion protein encodes the Pdgfra extracellular ligand binding domain fused to the cytoplasmic domain of Fgfr1. FACS analysis confirmed cell surface expression of the chimeric protein in embryonic fibroblasts. |