| First Author | Juriloff DM | Year | 2005 |
| Journal | Genomics | Volume | 85 |
| Issue | 1 | Pages | 139-42 |
| PubMed ID | 15607429 | Mgi Jnum | J:95944 |
| Mgi Id | MGI:3528123 | Doi | 10.1016/j.ygeno.2004.10.002 |
| Citation | Juriloff DM, et al. (2005) The open-eyelid mutation, lidgap-Gates, is an eight-exon deletion in the mouse Map3k1 gene. Genomics 85(1):139-42 |
| abstractText | The BALB/cGa mouse strain and its descendants, now called the SELH/Bc strain, have produced two waves of high frequency of spontaneous heritable mutations. One of these, the recessive lidgap-Gates (lg(Ga)) mutation, causes the same open-eyelids-at-birth phenotype as the gene knockout mutations of Map3k1 and co-maps to distal Chr 13. The lg(Ga) mutation is demonstrated to be a 27.5-kb deletion of exons 2-9 in the Map3k1 gene, the first spontaneous mutant allele described at this locus. The lg(Ga) mutation is consistent with a pattern suggesting that the waves of mutation in BALB/cGa and its descendants tend to be large deletions or ETn insertions, whose elevated rate of occurrence is due to an unknown mechanism. |
