| First Author | Nalio Ramos R | Year | 2022 |
| Journal | Cell | Volume | 185 |
| Issue | 7 | Pages | 1189-1207.e25 |
| PubMed ID | 35325594 | Mgi Jnum | J:322766 |
| Mgi Id | MGI:7259981 | Doi | 10.1016/j.cell.2022.02.021 |
| Citation | Nalio Ramos R, et al. (2022) Tissue-resident FOLR2(+) macrophages associate with CD8(+) T cell infiltration in human breast cancer. Cell 185(7):1189-1207.e25 |
| abstractText | Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage might be endowed with distinct roles on cancer progression and antitumor immunity. Here, we identify a discrete population of FOLR2(+) tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors. FOLR2(+) macrophages localize in perivascular areas in the tumor stroma, where they interact with CD8(+) T cells. FOLR2(+) macrophages efficiently prime effector CD8(+) T cells ex vivo. The density of FOLR2(+) macrophages in tumors positively correlates with better patient survival. This study highlights specific roles for tumor-associated macrophage subsets and paves the way for subset-targeted therapeutic interventions in macrophages-based cancer therapies. |
