| First Author | Romand R | Year | 1994 |
| Journal | Hear Res | Volume | 72 |
| Issue | 1-2 | Pages | 53-8 |
| PubMed ID | 8150745 | Mgi Jnum | J:19498 |
| Mgi Id | MGI:66435 | Doi | 10.1016/0378-5955(94)90205-4 |
| Citation | Romand R, et al. (1994) N-myc expression in the embryonic cochlea of the mouse. Hear Res 72(1-2):53-8 |
| abstractText | N-myc expression in the mouse embryo was examined during the late cochlear organogenesis. Tissue distribution of N-myc expression was histologically analyzed by in situ hybridization of the transcript in the cochlea between 15 and 18 days of gestation. At 15 days of gestation, N-myc expression was found very conspicuous in nervous structure of the cochlea such as the auditory nerve and the spiral ganglion. Moreover, N-myc was also present in the Kollikers organ and in the epithelium surrounding the cochlear canal. A few days later, N-myc expression was still clearly present in the Kollikers organ but less so in nervous structures. This study shows that cochlear tissues derived from the otic placode present a significant level of N-myc transcript during late embryogenesis. N-myc expression seems to be related to cell differentiation in the inner ear. |
