| First Author | Nishi-Tatsumi M | Year | 2017 |
| Journal | FEBS Lett | Volume | 591 |
| Issue | 7 | Pages | 965-978 |
| PubMed ID | 28281280 | Mgi Jnum | J:241939 |
| Mgi Id | MGI:5904070 | Doi | 10.1002/1873-3468.12620 |
| Citation | Nishi-Tatsumi M, et al. (2017) A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes. FEBS Lett 591(7):965-978 |
| abstractText | Fatty acid synthase (Fasn) is a key component of energy metabolism that is dynamically induced by food intake. Although extensive studies have revealed a number of transcription factors involved in the fasting/refeeding transition of Fasn expression in hepatocytes, much less evidence is available for adipocytes. Using the in vivo Ad-luc analytical system, we identified the inverted CCAAT element (ICE) around -100 nucleotides in the Fasn promoter as a critical cis-element for the refeeding response in adipocytes. Electrophoretic mobility shift assays and chromatin immunoprecipitation show that nuclear factor Y (NF-Y) binds to ICE specifically in refeeding states. Notably, the NF-Y binding to ICE is differently regulated between adipocytes and hepatocytes. These findings provide insights into the specific mechanisms controlling energy metabolism in adipocytes. |
