| Primary Identifier | MGI:1337096 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 19823 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin protein ligase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of neuron migration. Acts upstream of with a negative effect on reelin-mediated signaling pathway. Acts upstream of or within several processes, including brain development; intrinsic apoptotic signaling pathway in response to oxidative stress; and positive regulation of cysteine-type endopeptidase activity. Located in cytoplasm and nucleus. Part of Cul5-RING ubiquitin ligase complex. Is expressed in central nervous system; eye; and genitourinary system. Orthologous to human RNF7 (ring finger protein 7). PHENOTYPE: Mice homozygous for a null mutation display complete embryonic lethality during organogenesis with defects in angiogenesis, widespread apoptosis, impaired cell cycle progression of neuronal precursors and embryonic growth retardation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
