Primary Identifier | MGI:3045334 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 240697 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ATP binding activity and DNA binding activity. Acts upstream of or within meiosis I cell cycle process; oogenesis; and spermatogenesis. Predicted to be active in nucleus. Orthologous to human MCMDC2 (minichromosome maintenance domain containing 2). PHENOTYPE: Homozygous knockout mice of both sexes are sterile as a result of abnormal meiosis. This in turn is caused by defective double-strand break DNA repair. [provided by MGI curators] |