Primary Identifier | MGI:1349415 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 26754 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables enzyme binding activity and macrophage migration inhibitory factor binding activity. Acts upstream of or within regulation of cell cycle. Part of COP9 signalosome. Is expressed in several structures, including 1st branchial arch; central nervous system; cranium; genitourinary system; and sensory organ. Orthologous to human COPS5 (COP9 signalosome subunit 5). PHENOTYPE: Homozygous null mice die soon after implantation and exhibit growth-retardation, decrease in cell proliferation, and an increase in cell apoptosis. [provided by MGI curators] |