| Primary Identifier | MGI:2442988 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 211673 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable guanyl-nucleotide exchange factor activity; myosin binding activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in several processes, including negative regulation of GTPase activity; negative regulation of actin filament polymerization; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of with a positive effect on protein glycosylation. Predicted to be located in several cellular components, including Golgi apparatus; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be part of small nuclear ribonucleoprotein complex. Is expressed in brain. Orthologous to human ARFGEF1 (ARF guanine nucleotide exchange factor 1). PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality, absent gastric milk and decreased brain size with increased neuron apoptosis, abnormal axon guidance and hypersensitivity to glutamate. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
