| Primary Identifier | MGI:2662992 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 269181 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Involved in N-glycan processing. Acts upstream of or within protein N-linked glycosylation. Predicted to be located in peroxisome. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human MGAT4A (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A). PHENOTYPE: Mice homozygous for a knock-out allele show defects in glucose-stimulated insulin secretion, impaired cellular glucose import, increased susceptibility to weight gain, hyperglycemia, impaired glucose tolerance, insulin resistance, high free fatty acid and triglyceride levels, and hepatic steatosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
