| Primary Identifier | MGI:1338762 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 14200 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables bHLH transcription factor binding activity and transcription corepressor activity. Involved in several processes, including heart development; negative regulation of calcineurin-NFAT signaling cascade; and osteoblast differentiation. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in Z disc and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; periodontal ligament; and urinary system. Orthologous to human FHL2 (four and a half LIM domains 2). PHENOTYPE: Mice homozygous for a targeted null mutation display osteopenia and osteoporosis; cardiovascular development is normal but cardiac hypertrophy develops in mutants in response to beta-adrenergic stimulation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
