| Primary Identifier | MGI:1924117 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 76867 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables peptidase activity. Involved in several processes, including cellular response to unfolded protein; membrane protein proteolysis; and positive regulation of protein processing. Located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Orthologous to human RHBDD1 (rhomboid domain containing 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased tunicamycin-induced endoplasmic reticulum stress with significant weight loss and hepatic steatosis, and an increased inflammatory response and reduced survival in response to LPS injection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
