| Primary Identifier | MGI:107357 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 16331 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable inositol-4,5-bisphosphate 5-phosphatase activity. Acts upstream of or within several processes, including determination of adult lifespan; negative regulation of B cell proliferation; and regulation of hemopoiesis. Predicted to be located in actin filament and cortical cytoskeleton. Predicted to be active in cytosol. Is expressed in several structures, including integumental system; nervous system; respiratory system; skeleton; and spleen. Used to study Paget's disease of bone and systemic lupus erythematosus. Orthologous to human INPP5D (inositol polyphosphate-5-phosphatase D). PHENOTYPE: Homozygous null mice fail to reject fully mismatched allogeneic marrow grafts, do not develop graft versus host disease, and show enhanced survival after such transplants. Homozygous splice site mutants exhibit wasting, granulocytic lung infiltration anddefective cytolysis by NK cells and CTLs. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
