| Primary Identifier | MGI:1344392 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 23830 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable SNARE binding activity; calcium-dependent cysteine-type endopeptidase activity; and cytoskeletal protein binding activity. Involved in several processes, including cellular response to insulin stimulus; positive regulation of transport; and type B pancreatic cell apoptotic process. Acts upstream of or within positive regulation of type B pancreatic cell apoptotic process. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and mitochondrion. Predicted to be active in cytoplasm. Is expressed in dorsal root ganglion and renal calyx. Human ortholog(s) of this gene implicated in obesity; pancreatic cancer; polycystic ovary syndrome; and type 2 diabetes mellitus. Orthologous to human CAPN10 (calpain 10). PHENOTYPE: Mice homozygous for a knock-out allele exhibit resistance to ryanodine- and palmitate-induced pancreatic apoptosis. Mice homozygous for a different knock-out allele exhibit increased adiposity, body and organ weights, and leptin serum levels on background containing LG/J. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
