Primary Identifier | MGI:109579 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 20724 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including extracellular matrix organization; prostate gland morphogenesis; and regulation of epithelial cell proliferation. Located in sarcoplasm. Is active in cornified envelope. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and sensory organ. Orthologous to human SERPINB5 (serpin family B member 5). PHENOTYPE: Mice homozygous for one null allele displayed peri-implantation lethality with impaired endoderm development and attenuated inner cell mass growth. Mice homozygous for another null allele were viable and fertile with no gross abnormalities. [provided by MGI curators] |