| Primary Identifier | MGI:88229 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 12269 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in several processes, including negative regulation of complement activation, classical pathway; regulation of opsonization; and response to symbiotic bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space and plasma membrane. Is expressed in foregut-midgut junction; midgut; midgut loop; renal calyx; and renal pelvis. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPA (complement component 4 binding protein alpha). PHENOTYPE: Male mice exhibit normal fertility and spermatozoa morphology and function. Mice homozygous for the same allele exhibit increase IL6 serum levels in response to LPS injection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
