| Primary Identifier | MGI:2443362 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 240754 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable SH2 domain binding activity and protein kinase binding activity. Acts upstream of or within antigen receptor-mediated signaling pathway and lymphocyte activation. Predicted to be located in Golgi apparatus; cytosol; and membrane. Predicted to be active in plasma membrane. Orthologous to human LAX1 (lymphocyte transmembrane adaptor 1). PHENOTYPE: Homozygous null mice exhibit spontaneous germinal center formation and increased IgG1, IgG2a, and IgE levels. T and B cells are hyperresponsive upon engagement of T or B AgRs. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
