| Primary Identifier | MGI:1098226 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 381293 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including ATP binding activity; ATP hydrolysis activity; and plus-end-directed microtubule motor activity. Involved in several processes, including brain development; negative regulation of neuron apoptotic process; and regulation of myelination. Predicted to be located in several cellular components, including Flemming body; cytosol; and spindle midzone. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Predicted to colocalize with plasma membrane. Is expressed in heart and retina. Human ortholog(s) of this gene implicated in Meckel syndrome and primary autosomal recessive microcephaly. Orthologous to human KIF14 (kinesin family member 14). PHENOTYPE: Mice homozygous for a spontaneous mutation or targeted allele exhibit severe brain malformations, neurological defects and hypomyelination. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
