| Primary Identifier | MGI:1915021 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 67771 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including actin filament organization; lamellipodium organization; and smooth muscle cell migration. Located in lamellipodium. Is expressed in cortical plate. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human ARPC5 (actin related protein 2/3 complex subunit 5). PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality between E9.5 and E10.5 with incomplete caudal and rostral neuropore closure, absent pharyngeal arches and cardiac outflow tract, impaired somite development, and failure of initiation of embryo turning. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
