Primary Identifier | MGI:101776 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 16872 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Acts upstream of or within several processes, including negative regulation of apoptotic process; neuron differentiation; and placenta development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in combined pituitary hormone deficiency. Orthologous to human LHX4 (LIM homeobox 4). PHENOTYPE: Mutations in this gene result in abnormal lung development and neonatal lethality. [provided by MGI curators] |