| Primary Identifier | MGI:1917706 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 70456 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables pyruvate transmembrane transporter activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Acts upstream of or within mitochondrial pyruvate transmembrane transport and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in mitochondrion. Is active in mitochondrial inner membrane. Is expressed in several structures, including brain; early conceptus; heart; and liver. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). PHENOTYPE: Mice homozygous for a null allele die during organogenesis. Mice homozygous for a truncated allele display defects in mitochondrial physiology and impaired glucose-stimulated insulin secretion. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
