| Primary Identifier | MGI:88334 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 12503 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein tyrosine kinase binding activity. Acts upstream of or within T cell receptor signaling pathway and positive regulation of protein localization to cell surface. Located in Golgi apparatus and plasma membrane. Part of alpha-beta T cell receptor complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in immunodeficiency 25. Orthologous to human CD247 (CD247 molecule). PHENOTYPE: Homozygotes for targeted null mutations exhibit greatly reduced numbers of CD4+CD8+ cells, and near absence of CD4+CD8-, CD4-CD8+ cells, and TCR expression in the thymus, but the presence of single positive T cells in lymph nodes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
