Primary Identifier | MGI:2685055 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 240892 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable MAP kinase phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade. Predicted to be located in sarcomere. Predicted to be active in cytoplasm. Is expressed in heart; limb muscle; lung; skeletal muscle; and somite. Orthologous to human STYXL2 (serine/threonine/tyrosine interacting like 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete lethality throughout fetal growth and development, edema in some dead fetuses, and severe disruption of the sarcomeric structures in fetal cardiomyocytes. [provided by MGI curators] |