| Primary Identifier | MGI:1196370 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 100039795 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in negative regulation of T cell activation and regulation of RNA splicing. Acts upstream of or within several processes, including homeostasis of number of cells within a tissue; insulin secretion; and response to glucose. Located in tight junction. Is expressed in embryo; forebrain; medial ganglionic eminence; and retina. Orthologous to human ILDR2 (immunoglobulin like domain containing receptor 2). PHENOTYPE: Mice homozygous for an ENU-induced stop mutation at threonine-87 display a reduced pancreatic beta-cell replication rate, decreased beta-cell mass, reduced insulin/glucose ratio in blood, impaired glucose tolerance, and persistent mild hypoinsulinemia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
