| Primary Identifier | MGI:1330808 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 15490 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity; 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity; and estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Involved in brain development; embryonic organ development; and steroid metabolic process. Acts upstream of or within several processes, including cholesterol biosynthetic process; embryonic skeletal system development; and nervous system development. Located in endoplasmic reticulum. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including autopod; nervous system; reproductive system; sensory organ; and trophectoderm. Orthologous to human HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7). PHENOTYPE: Mice homozygous for a targeted allele exhibit embryonic lethality, abnormal brain development, abnormal branchial arches, pericardial effusion, and abnormal cardiovascular development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
