Primary Identifier | MGI:109578 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 21339 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA binding activity. Predicted to act upstream of or within transcription by RNA polymerase I. Part of RNA polymerase transcription factor SL1 complex. Orthologous to human TAF1A (TATA-box binding protein associated factor, RNA polymerase I subunit A). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality before implantation. In vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming blastocysts. [provided by MGI curators] |