| Primary Identifier | MGI:109366 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 16526 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables channel activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including chloride transmembrane transport; glutamate secretion; and neuronal action potential. Acts upstream of or within G protein-coupled receptor signaling pathway; potassium ion transport; and regulation of membrane potential. Located in astrocyte projection; dendrite; and plasma membrane. Part of voltage-gated potassium channel complex. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including brain; early conceptus; limb; olfactory epithelium; and secondary oocyte. Orthologous to human KCNK2 (potassium two pore domain channel subfamily K member 2). PHENOTYPE: Homozygous null mice display increased sensitivity to pharmacologically induced seizures and ischemia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
