Primary Identifier | MGI:109366 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 16526 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables voltage-gated potassium channel activity. Involved in chemical postsynaptic transmission. Acts upstream of or within G protein-coupled receptor signaling pathway; potassium ion transmembrane transport; and regulation of membrane potential. Located in plasma membrane. Part of voltage-gated potassium channel complex. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including brain; early conceptus; limb; olfactory epithelium; and secondary oocyte. Orthologous to human KCNK2 (potassium two pore domain channel subfamily K member 2). PHENOTYPE: Homozygous null mice display increased sensitivity to pharmacologically induced seizures and ischemia. [provided by MGI curators] |