Primary Identifier | MGI:1915889 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 226830 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II complex binding activity and histone H3K36 methyltransferase activity. Involved in negative regulation of cell population proliferation and peptidyl-lysine dimethylation. Located in cytosol and nucleus. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; nasal cavity epithelium; and nervous system. Orthologous to human SMYD2 (SET and MYND domain containing 2). PHENOTYPE: Mice homozygous for a targeted allele exhibit increased circulating total and LDL cholesterol levels and decreased circulating sodium and chloride levels. [provided by MGI curators] |