Primary Identifier | MGI:98933 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 22353 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables hormone activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of protein catabolic process; and regulation of protein localization. Acts upstream of or within regulation of signal transduction. Predicted to be located in neuronal cell body. Predicted to be active in neuron projection. Is expressed in several structures, including alimentary system; genitourinary system; hair root sheath; nervous system; and vomeronasal organ. Used to study primary pulmonary hypertension. Human ortholog(s) of this gene implicated in alcohol use disorder and pulmonary sarcoidosis. Orthologous to human VIP (vasoactive intestinal peptide). PHENOTYPE: Homozygous null mutants display abnormal circadian rhythyms with a shorter period, abnormal phase, and in 1/4 arrhythmic circadian persistence. [provided by MGI curators] |