| Primary Identifier | MGI:2148258 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 111174 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables trace-amine receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and phospholipase C-activating G protein-coupled receptor signaling pathway. Acts upstream of or within G protein-coupled receptor signaling pathway. Is active in plasma membrane. Used to study schizophrenia. Orthologous to human TAAR1 (trace amine associated receptor 1). PHENOTYPE: Mice homozygous for a null mutation display decreased prepulse inhibition and increased sensitivity to amphetamines. Mice homozygous for another knock-out allele exhibit increased sensitivity to MDMA-induced hyperthermia, brain dopamine and serotonin levels, and induced hyperactivity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
