|  Help  |  About  |  Contact Us

Protein Coding Gene : Ccn2 cellular communication network factor 2

Primary Identifier  MGI:95537 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  14219
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables heparin binding activity and integrin binding activity. Acts upstream of or within several processes, including cartilage development; cell surface receptor signaling pathway; and chondrocyte proliferation. Located in extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Orthologous to human CCN2 (cellular communication network factor 2).
PHENOTYPE: Homozygous null mice die at birth from respiratory failure due to axial skeletal defects and pulmonary hypoplasia associated with reduced cell proliferation, enhanced apoptosis and altered pneumocyte maturation. Osteogenesis is impaired due to impaired chondrogenesis and growth plate angiogenesis. [provided by MGI curators]
  • synonyms:
  • cellular communication network factor 2,
  • Ccn2,
  • Ctgf,
  • MGD-MRK-9804,
  • Fisp12,
  • fibroblast inducible secreted protein,
  • connective tissue growth factor,
  • hypertrophic chondrocyte-specific gene product 24,
  • Hcs24

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

2 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

0 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

3 Driver For