| Primary Identifier | MGI:103009 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 13822 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables PH domain binding activity and spectrin binding activity. Predicted to be involved in actomyosin structure organization and positive regulation of protein localization to cell cortex. Predicted to act upstream of or within actin cytoskeleton organization and regulation of cell shape. Predicted to be located in several cellular components, including actin cytoskeleton; cell cortex; and nucleoplasm. Predicted to be part of COP9 signalosome. Predicted to be active in cytoskeleton and plasma membrane. Is expressed in several structures, including bone; central nervous system; sensory organ; thymus; and urinary system. Orthologous to human EPB41L2 (erythrocyte membrane protein band 4.1 like 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal glutamatergic synapse formation, AMPAR responses and long-term potentiation. Male mice homozygous for a knock-out allele exhibit normal fertility. Male mice homozygous for a gene trap allele on a mixed background are infertile. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
