| Primary Identifier | MGI:1920030 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 72780 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables frizzled binding activity and heparin binding activity. Involved in blood vessel remodeling; positive regulation of non-canonical Wnt signaling pathway; and sprouting angiogenesis. Acts upstream of or within angiogenesis; branching involved in labyrinthine layer morphogenesis; and positive regulation of canonical Wnt signaling pathway. Located in extracellular region. Is expressed in several structures, including embryo ectoderm; genitourinary system; heart; limb; and skeleton. Orthologous to human RSPO3 (R-spondin 3). PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality during organogenesis, embryonic growth arrest, and impaired fetal placental vascular development. Mice homozygous for a conditional allele activated in limbs exhibit slight limb shortening. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
