| Primary Identifier | MGI:95815 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 14806 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ligand-gated monoatomic ion channel activity. Involved in detection of cold stimulus involved in thermoception. Acts upstream of or within several processes, including behavioral fear response; chemical synaptic transmission; and modulation of chemical synaptic transmission. Located in neuronal cell body; postsynaptic density; and presynaptic membrane. Part of kainate selective glutamate receptor complex. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; mossy fiber rosette; and postsynaptic membrane. Is expressed in several structures, including arterial system; central nervous system; eye; gut; and metanephros. Human ortholog(s) of this gene implicated in Huntington's disease and autosomal recessive intellectual developmental disorder 6. Orthologous to human GRIK2 (glutamate ionotropic receptor kainate type subunit 2). PHENOTYPE: Homozygotes for a targeted null mutation exhibit hippocampal neurons with reduced sensitivity to kainate and reduced susceptibility to the seizure-inducing effects of kainate administration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
