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Protein Coding Gene : Lims1 LIM and senescent cell antigen-like domains 1
Primary Identifier  MGI:1195263 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  110829
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable protein kinase binding activity and zinc ion binding activity. Acts upstream of or within several processes, including negative regulation of cell population proliferation; negative regulation of hepatocyte apoptotic process; and positive regulation of integrin-mediated signaling pathway. Located in focal adhesion. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and liver and biliary system. Orthologous to human LIMS1 (LIM zinc finger domain containing 1).
PHENOTYPE: Homozygous null mice die shortly after implantation and have a disorganized egg cylinder by E5.5, which is degenerated by E6.5. E5.5 null embryos exhibit decreased cell proliferation and excessive cell death. [provided by MGI curators]
  • synonyms:
  • expressed sequence AU021743,
  • RIKEN cDNA 2310016J22 gene,
  • AU021743,
  • RIKEN cDNA 4921524A02 gene,
  • MGI:2445157,
  • Lims1l,
  • MGI:2143741,
  • AW551584,
  • C430041B13Rik,
  • LIM and senescent cell antigen-like domains 1,
  • PINCH1,
  • Lims1,
  • MGI:2143635,
  • expressed sequence AI507642,
  • expressed sequence AW551584,
  • MGI:1919149,
  • MGI:2143862,
  • 4921524A02Rik,
  • RIKEN cDNA C430041B13 gene,
  • 2310016J22Rik,
  • LIM and senescent cell antigen-like domains 1-like,
  • AI507642,
  • MGI:1914678
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