| Primary Identifier | MGI:1921997 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 74747 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables 14-3-3 protein binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Acts upstream of or within several processes, including cellular response to dexamethasone stimulus; negative regulation of TOR signaling; and negative regulation of glycolytic process. Located in mitochondrion. Is expressed in several structures, including cerebral cortex subventricular zone; reproductive system; and retina nuclear layer. Orthologous to human DDIT4 (DNA damage inducible transcript 4). PHENOTYPE: Homozygous null mice show resistance to hyperoxia-induced retinopathy. Mice homozygous for another knock-out allele exhibit normal testis development and fertility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
