| Primary Identifier | MGI:109198 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 13688 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables eukaryotic initiation factor 4E binding activity and translation repressor activity. Involved in several processes, including memory; negative regulation of translational initiation; and social behavior. Acts upstream of or within TOR signaling and insulin receptor signaling pathway. Predicted to be located in nucleus. Predicted to be active in neuronal ribonucleoprotein granule and postsynapse. Is expressed in heart; liver; and lung. Used to study autism spectrum disorder. Orthologous to human EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2). PHENOTYPE: Mice homozygous for a knock-out allele display altered synaptic transmission, impaired spatial learning, and long-term memory deficits, and autism-like behaviors including abnormal social investigation, repetitive behaviors and abnormal vocalization. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
