| Primary Identifier | MGI:1860494 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 56200 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables double-stranded RNA binding activity and identical protein binding activity. Involved in positive regulation of canonical NF-kappaB signal transduction and positive regulation of myeloid dendritic cell cytokine production. Acts upstream of or within response to exogenous dsRNA and response to virus. Located in cytosol. Is expressed in several structures, including 1st branchial arch; cerebral cortex; early conceptus; genitourinary system; and limb. Orthologous to human DDX21 (DExD-box helicase 21). PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit embryonic lethality. Mice homozygous for a knock-out allele show embryonic growth retardation and complete embryonic lethality prior to organogenesis, with morula-like embryos failing to hatch from the zona pellucida and to form in vitro outgrowths. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
