| Primary Identifier | MGI:2389177 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 216028 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within positive regulation of amyloid-beta formation and positive regulation of synapse assembly. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; future brain; and male reproductive gland or organ. Orthologous to human LRRTM3 (leucine rich repeat transmembrane neuronal 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced excitatory synapse development with reduced excitatory synapse density, mESPC amplitude, and abnormal synaptic depression. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
