| Primary Identifier | MGI:1354950 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 641340 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable nuclear receptor binding activity and transcription coactivator activity. Involved in autophagy; regulation of lipid kinase activity; and response to endoplasmic reticulum stress. Part of phosphatidylinositol 3-kinase complex, class III. Orthologous to human NRBF2 (nuclear receptor binding factor 2). PHENOTYPE: Mice homozygous null for this allele develop focal liver necrosis and ductular reaction in the liver and cells show impaired autophagosome maturation and increased susceptibility to ER stress. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
