Primary Identifier | MGI:1916813 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 69563 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables enzyme inhibitor activity. Acts upstream of or within negative regulation of ATPase-coupled calcium transmembrane transporter activity; negative regulation of calcium ion import into sarcoplasmic reticulum; and response to wounding. Located in sarcoplasmic reticulum membrane. Is expressed in several structures, including diaphragm; heart; leg muscle; somite; and tongue. Orthologous to human MRLN (myoregulin). PHENOTYPE: Mice homozygous for a knock-out allele show improved exercise performance and enhanced Ca2+ handling in skeletal muscle. Mice homozygous for another knock-out exhibit reduced myofiber numbers and muscle regeneration. [provided by MGI curators] |