| Primary Identifier | MGI:1298375 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 104248 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein domain specific binding activity; protein phosphatase 2B binding activity; and protein phosphatase inhibitor activity. Predicted to contribute to nucleosome binding activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to act upstream of or within signal transduction. Predicted to be located in aggresome; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in heart. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CABIN1 (calcineurin binding protein 1). PHENOTYPE: Homozygous null mutants exhibit embryonic lethality during organogenesis. Mice producing a truncated protein exhibit elevated levels of serum IgG1, IgG2b and IgE, produce more IgG1 in response to T-cell dependent antigen, and have enhanced expression of cytokines in response to anti-CD3 stimulation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
