| Primary Identifier | MGI:96982 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 17319 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cytokine activity; phenylpyruvate tautomerase activity; and protease binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of icosanoid secretion; and regulation of signal transduction. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; cellular senescence; and regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor). PHENOTYPE: Homozygotes for three distinct targeted alleles show varying immune system defects. Among these are increased endotoxin resistance and Pseudomonas clearance; reduced size of induced fibrosarcomas and lower mitotic index; and decreased contact hypersensitivity. A specific point mutation that blocks the peptide's nuclease activity blocks it's apoptotic activity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
