| Primary Identifier | MGI:97791 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 19205 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome and negative regulation of neuron differentiation. Acts upstream of with a negative effect on gene expression. Acts upstream of or within neurogenesis and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain; central nervous system ganglion; connective tissue; genitourinary system; and sensory organ. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1). PHENOTYPE: Mice homozygous for a knock-out allele die before E6.5. Mice homozygous for a conditional allele activated in neuronal stem cells (NSCs) exhibit premature death, and non-obstructive hydrocephaly with loss of ependymal cells due to precocious NSC differentiation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
