| Primary Identifier | MGI:104767 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 625249 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Involved in negative regulation of ferroptosis and response to oxidative stress. Acts upstream of or within several processes, including nervous system development; response to lipopolysaccharide; and spermatogenesis. Located in cytosol; mitochondrion; and nuclear envelope. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4). PHENOTYPE: Gastrulation is impaired and homozygous mutant embryos consequently die during early embryonic development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
