| Primary Identifier | MGI:1354170 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 100503659 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables transmembrane transporter binding activity. Involved in negative regulation of calcium ion-dependent exocytosis and negative regulation of voltage-gated calcium channel activity. Located in plasma membrane and secretory granule. Colocalizes with growth cone. Is expressed in nervous system. Orthologous to human CBARP (CACN subunit beta associated regulatory protein). PHENOTYPE: Mice homozygous for a knock-out allele show alterations in presynaptic striatal nicotinic acetylcholine receptors and reduced persistent nicotine-induced dopamine release in striatal synaptosomes. Homozygous KO also leads to lower body weight, reduced grip strength, hypoactivity, increased sociability, decreased startle reflex and enhanced spatial working memory. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
